EVA STAR Trefferanzeige

Volltext Singh_Vibhuti_pdfa.pdf1.pdf (5,0 MB)
URN (für Zitat) http://nbn-resolving.org/urn:nbn:de:swb:90-236891
Titel Attending persistent T cell activation in alopecia areata : A therapeutic option
Autor Singh, Vibhuti
Institution Institut für Toxikologie und Genetik (ITG) (ITG)
Dokumenttyp Buch
Verlag Karlsruhe
Jahr 2011
Hochschulschrift Dissertation
Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut für Toxikologie und Genetik (ITG) (ITG)
Prüfungsdaten: 13.07.2011
Referent/Betreuer: Prof. M. Zöller
Abstract Alopecia areata an autoimmune disease of the hair follicle is most efficiently cured by contact sensitizers (Delayed type hypersenstivity). The curative effect is the expansion of myeloid derived suppressor cells which can suppress the autoreactive T cells and induce apoptosis via mitochondrial pathway. Another aspect is by hindrance of the antigen presentation to lymphocytes. CD44 with CD49d plays an important role in homing of lymphocytes and blockade of these can help cure Alopecia areata.