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Volltext Oelmeier_Stefan.pdf1.pdf (5,0 MB)
URN (für Zitat) http://nbn-resolving.org/urn:nbn:de:swb:90-303892
Titel Aqueous two phase extraction of proteins: From molecular understanding to process development
Autor Oelmeier, Stefan A.
Institution Institut für Bio- und Lebensmitteltechnik (BLT)
Dokumenttyp Buch
Verlag Karlsruhe
Jahr 2012
Hochschulschrift Dissertation
Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten: 28.09.2012
Referent/Betreuer: Prof. J. Hubbuch
Abstract A high throughput screening method was implemented and applied to an industrial separation task. Previously reported correlations between protein descriptors and distribution were evaluated. A new approach to screen ATPS for their industrial application was devised and put to use for the selection of ATPSs used in centrifugal partitioning chromatography. A new modeling approach based on molecular dynamics was set up. This approach was validated using single PEG molecules in solution.